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Answer: OPPOSITE
OPPOSITE is a crossword puzzle answer that we have spotted 16 times.
Facing
Like the prepositions in 23-, 35- and 46-Across
Antithesis
Antithetical
Black, to white
Night, to day
Antonym
On the other side
Directly across from
For, for against
Reverse
Polar
Left, to right
Top, to bottom
Inverse
Small, to large