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Answer: WORRY
WORRY is a crossword puzzle answer that we have spotted 28 times.
Fret
Dog or hound
"What, me ___?"
Cause of wrinkles
Trouble
"What, me ___?" (Mad magazine motto)
Cause of fitful sleep
It "often gives a small thing a big shadow": old proverb
Stew
Anxiety
"Interest paid on trouble before it falls due," per W. R. Inge
Be fretful
Lose sleep over (with "about")
"What, me ___?": Alfred E. Neuman line
Concern
See 7-Down
End of Alfred E. Neuman's slogan
Feel uneasy
Be in a fretful mood
Producer of wrinkles, it's said
Distress
Get into a stew
Feels anxious
Fuss
"Don't ___, Be Happy"
Cause of a furrowed brow
"Hattie Harmony: ___ Detective" (kids' book by Elizabeth Olsen and Robbie Arnett)
You might calmly tell someone not to do this