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Answer: UPTHEANTE
UPTHEANTE is a crossword puzzle answer that we have spotted 10 times.
Get serious, gambler-style
Call one's bluff, in a way
Call one's bluff
Put more at risk
Play for higher stakes
Raise stakes in a game ... and a hint to a hidden feature of five Down puzzle answers
Increase what is at stake ... or a hint to answering 20-, 30- and 46-Across
Put more at stake
Make things interesting, so to speak
Increase what's at stake