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Answer: SUREST
SUREST is a crossword puzzle answer that we have spotted 21 times.
Least equivocal
Least vacillating
Optimal, as a bet
Like the risk to bet on, maybe
Most reliable
Superlatively decided
Most confident
Like the best bet
Most certain
Most likely to succeed
Most definite
Most indisputable
Most dependable
Best, as a bet
Most convinced
Most likely to work
Superlatively certain
Most likely
Least iffy
Least tentative
Least in question