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Answer: SOREST
SOREST is a crossword puzzle answer that we have spotted 33 times.
Hurting the most
Most angry
Most achy
Most upset
Most painful
Most irritated
Most put out
Most vexed
Least content
Most peeved
Achy to the max
Most piqued
Most achy or angry
Most tender
Most miffed
Most ticked off
Most in need of massage
Put out the most
Most distressed
Aching the most
Most tender to the touch
Most inflamed
Most painful to the touch
Most aching
Most in need of liniment
Most likely to groan
Most ticked-off
Least comfortable
With the most aches
Most affected by a workout
Supremely irked
Least gracious, as a loser
Supremely miffed