Answer: SON
SON is a crossword puzzle answer that we have spotted 450 times.
    - Part of the Holy Trinity
 
    - Word in many business names
 
    - Junior
 
    - Prodigal ___
 
    - Prince, e.g.
 
    - Michael Douglas, to Kirk
 
    - Zeus, to Cronus
 
    - Patronizing term, maybe
 
    - Primogeniture beneficiary
 
    - Cain was the first
 
    - One who passes on a name, often
 
    - Tom, to the piper
 
    - Ampersand follower, sometimes
 
    - "Favorite" person
 
    - Royal wish
 
    - Henry V, to Henry IV
 
    - Last word in many company names
 
    - Junior, usually
 
    - Word ending many company names
 
    - "My boy"
 
    - One may be a favorite
 
    - Follower of "&" in many business names
 
    - Name passer, perhaps
 
    - 46-Down, to Aphrodite
 
    - Jesus, with "the"
 
    - Junior, e.g.
 
    - Trinity member
 
    - William, to Charles
 
    - ___ of a gun
 
    - Bart, to Homer Simpson
 
    - George W., to George
 
    - Chip off the old block
 
    - Junior, to Senior
 
    - 43-Down, to Adam
 
    - Labor day arrival?
 
    - Potential heir
 
    - William, to Diana
 
    - Trinity component
 
    - "Favorite" one
 
    - IV, to III
 
    - Young fellow
 
    - Roughly one of every two deliveries
 
    - 38-Down was the second one
 
    - Ham, to Noah
 
    - End of some company names
 
    - "Listen, ___ ..."
 
    - II or III, say
 
    - III, to Jr.
 
    - Male delivery?
 
    - "My ___, the doctor"
 
    - Many a delivery
 
    - Mama's boy
 
    - Daughter's opposite
 
    - Y beneficiary
 
    - Magritte's "The ___ of Man"
 
    - RCA competitor
 
    - 8-Down, with "the"
 
    - Holy Trinity part
 
    - Sequel title starter
 
    - II or III
 
    - Prince, to a king
 
    - ___ of God
 
    - Sequel title starter, sometimes
 
    - Daughter's counterpart
 
    - Delivery possibility
 
    - George W., to George H. W.
 
    - IV to III, maybe
 
    - Bush 43, to Bush 41
 
    - Business partner, sometimes
 
    - Male delivery
 
    - Heir, perhaps
 
    - Larry Hagman, to Mary Martin
 
    - Tiny Tim, to Bob Cratchit
 
    - Alan Alda, to Robert Alda
 
    - Business partner, perhaps
 
    - Boy, to Tarzan
 
    - Icarus, to Daedalus
 
    - Ishmael, to Abraham
 
    - Last word of Kipling's "If"
 
    - "Sanford and ___"
 
    - "A ___ of the Circus" (John Irving novel)
 
    - Male offspring
 
    - Michael, to Kirk
 
    - Jack Osbourne, to Ozzy
 
    - Dauphin
 
    - Luke, to 57-Down
 
    - Junior, often
 
    - Junior, most of the time
 
    - Mamma's boy
 
    - George W. Bush, to George H.W. Bush
 
    - Henry VIII's desire
 
    - Enrique Iglesias, to Julio
 
    - Trinity figure
 
    - Arlo, to Woody
 
    - Heir, sometimes
 
    - Mama's boy?
 
    - Business inheritor, often
 
    - Cupid, to Venus
 
    - Isaac, to Abraham
 
    - George W., to George H.W.
 
    - Male issue
 
    - Beaver, to Ward
 
    - Leif, to Eric the Red
 
    - "That's a joke, ___!"
 
    - Grand duke, to a czar
 
    - Simba, to Mufasa
 
    - Nemo, to Marlin
 
    - "___ of a gun!"
 
    - Sean, to Yoko
 
    - John Quincy Adams, to John Adams
 
    - Hamlet, to Gertrude
 
    - Trinity part
 
    - Zak, to Ringo
 
    - You might give him the business
 
    - Heir, often
 
    - Charlie, to Martin
 
    - Boy
 
    - Luke, to Darth
 
    - Dad's lad
 
    - Dad, to Gramps
 
    - Rob Reiner, to Carl
 
    - Bart, to Homer
 
    - Mike, Robbie or Chip, in '60s TV
 
    - Family man
 
    - Abel, to 32 Across
 
    - Junior, for one
 
    - Junior partner, perhaps
 
    - Mom's boy
 
    - ''My __, the doctor''
 
    - Emilio, to Martin
 
    - Ben, to Jerry Stiller
 
    - ''Junior'' in the family
 
    - Start of some sequels
 
    - Dad's boy
 
    - Junior, to Mom or Dad
 
    - ''Dombey and __''
 
    - Baby in blue
 
    - Junior partner, sometimes
 
    - Ham, long ago
 
    - 76 Across, to Carl
 
    - Certain offspring
 
    - Jupiter, to Saturn
 
    - ''You'll be a man, my __''
 
    - Dad, to Grandpa
 
    - Business partner, at times
 
    - "___ of a Preacher Man"
 
    - "Carry On Wayward ___"
 
    - "Native ___" (Richard Wright novel)
 
    - "___ of Frankenstein"
 
    - Belshazzar, to Nebuchadnezzar, in the Bible
 
    - III to II, e.g.
 
    - Business inheritor, perhaps
 
    - ''___ of a Preacher Man''
 
    - Solomon, to David
 
    - ''Native ___''
 
    - Bloodline extender
 
    - Cain, to Adam
 
    - "Dombey and ___" (Dickens novel)
 
    - Gun's offspring?
 
    - Dad's little man
 
    - Prince William, to Prince Charles
 
    - Abel, to Adam
 
    - Second person in the Trinity
 
    - Stork's delivery, sometimes
 
    - Ampersand follower, perhaps
 
    - Ham, to 31-Across
 
    - Ampersand follower, often
 
    - About one of every two deliveries
 
    - Dombey's partner
 
    - Family tree branch
 
    - About one of every two deliveries?
 
    - Boy child
 
    - IV to III?
 
    - Business inheritor, sometimes
 
    - Figs.
 
    - Will party
 
    - Heir, but not an heiress
 
    - Small business successor, maybe
 
    - Didactic term of address
 
    - One learning about the birds and the bees?
 
    - Half of many a business partnership
 
    - Chip off the old block, maybe
 
    - W, to Barbara
 
    - Elroy, to George Jetson
 
    - Gun relative?
 
    - 49 Down's boy
 
    - Offspring
 
    - Pluto, to Saturn
 
    - "Native ___"
 
    - Harry, to Charles
 
    - Abel, to Eve
 
    - Orestes, to Agamemnon
 
    - Hector, to Hecuba
 
    - "You'll be a man, my ___"
 
    - "Junior" in the family
 
    - "Dombey and ___"
 
    - "___ of Rambow"
 
    - Phil, Bruce or Sandy McMath, to Syd
 
    - Johnny Rivers hit, "Seventh ___"
 
    - Labor result, often
 
    - Male heir
 
    - Male child
 
    - Male descendant
 
    - Ares, to Zeus
 
    - Emilio Estevez, to Martin Sheen
 
    - Ford's Edsel, e.g.
 
    - Father's Day gift giver, perhaps
 
    - "Fortunate ___" (Creedence Clearwater Revival song)
 
    - Anderson Cooper, to Gloria Vanderbilt
 
    - Absalom, to David
 
    - Cain, to Eve
 
    - Favorite person?
 
    - Charlie Sheen, to Martin
 
    - Business partner, often
 
    - Word after an ampersand, maybe
 
    - Numbered Chan relative
 
    - Pugsley, to Gomez
 
    - Heir, at times
 
    - Father's pride
 
    - Daughter's sibling
 
    - Family member
 
    - Daughter's brother
 
    - One of the Trinity
 
    - Inheritor, often
 
    - Tim, to Bob Cratchit
 
    - Daddy's boy
 
    - Prince, to Cecil Fielder
 
    - "Dear ___ of memory, great heir of fame ...": Milton
 
    - One of two deliveries?
 
    - Almost all males, to Foghorn Leghorn
 
    - Holy Trinity member
 
    - Favorite ___
 
    - Perseus, to Zeus
 
    - Many a beneficiary
 
    - Jesus, vis-à-vis god
 
    - Addition to my family on 5/31/12
 
    - Reunion attendee
 
    - Possible heir
 
    - Little guy
 
    - Roughly one of every two deliveries?
 
    - He may be a junior
 
    - Founder's successor, often
 
    - Beau or Jeff, to Lloyd
 
    - Start of a sequel
 
    - Mom and Dad's boy
 
    - Stewie, to Lois
 
    - Wright's "Native ___"
 
    - Man child
 
    - "Son of a ___!"
 
    - Harry or William, to Charles
 
    - Heir, maybe, but not an heiress
 
    - Senior's junior
 
    - Dombey's partner?
 
    - Founder's successor, in some cases
 
    - "Dombey and ____" (Dickens)
 
    - Lamont, to Fred Sanford
 
    - Thor, to Odin
 
    - Labor result, about half the time
 
    - Ben, to Brian
 
    - "___ of the Pink Panther"
 
    - 43rd President, to the 41st President
 
    - Many an heir
 
    - Like a ___ to me
 
    - Colin Hanks, to Tom
 
    - Family address
 
    - "That's my boy!" recipient
 
    - With 56-Across, daughter's hubby
 
    - "That's my boy" recipient
 
    - Last word of Kipling's "If"
 
    - "Favorite" relative
 
    - Royal's wish
 
    - Chaney film, "___ of Dracula"
 
    - Future heir, perhaps
 
    - Most common labor issue
 
    - "Favorite" sibling
 
    - Scion
 
    - Sacha to Pierre
 
    - Moses, to Gwyneth
 
    - Boy of the house
 
    - Dad, to Granddad
 
    - Bret to Bobby
 
    - King's prince
 
    - George, to Prince William
 
    - Trinity third
 
    - Result of labor half the time?
 
    - Family's boy
 
    - One's boy
 
    - Close relative
 
    - Father's boy
 
    - Part of the Trinity
 
    - Every man but no woman
 
    - Prince George, to Prince William
 
    - Simba, to Sarabi
 
    - One who might be given the business
 
    - Hal, to Henry IV
 
    - Lad
 
    - Ampersand follower, maybe
 
    - Delivery outcome, sometimes
 
    - Neptune vis-à-vis Saturn
 
    - Qass, to Vijay Singh
 
    - That's my boy, really
 
    - Member of the family, often
 
    - "___ of Zorn"
 
    - Bart Simpson, to Marge
 
    - Certain 66 Across
 
    - Ben, to Jerry
 
    - Mark to Gordie
 
    - Ares, to Hera
 
    - Condescending address, maybe
 
    - Scott Eastwood, to Clint
 
    - Pugsley, to Morticia Addams
 
    - Boy in the family
 
    - Start of a sequel, sometimes
 
    - Cain was the first ever
 
    - Mother's Day host, often
 
    - This is an issue
 
    - Cain or Abel, to Adam
 
    - Royal wish, once
 
    - Grand duke vis-à-vis a czar
 
    - Romeo, to Lady Montague
 
    - Word after "&" in many a company name
 
    - Like father, like ___
 
    - Owen, to Stephen King
 
    - One who might follow into a family business
 
    - Family fellow
 
    - Dryden's "unfeather'd, two-legg'd" one
 
    - Young friend, to a good ol' boy
 
    - Partner of the Father and Holy Ghost
 
    - Methuselah, to Enoch
 
    - III or IV, maybe
 
    - One in a family photo
 
    - Family guy
 
    - My boy, to me
 
    - Tell's apple support
 
    - Member of the family
 
    - Gun offspring?
 
    - Noah's Ham, for one
 
    - Youngster's address
 
    - Nathan, to David
 
    - Dad, to Grandma
 
    - "Like father, like ___"
 
    - Family business partner
 
    - Apollo, to Zeus
 
    - Cain or Abel, to Adam and Eve
 
    - Pop's boy
 
    - Address like "my boy"
 
    - Jesus Christ, with "the"
 
    - Jesus, to Mary
 
    - Laertes, to Polonius
 
    - Homer, to Abe Simpson
 
    - 41-Across, often
 
    - Certain surname sharer
 
    - Luke, to Darth Vader ("Star Wars" spoiler)
 
    - End of an Easter reminder
 
    - Cain or Abel, for Eve
 
    - 2 Down, to Eve
 
    - Junior, to Dad
 
    - Ending of eight U.S. presidents' names
 
    - Luke, to Anakin
 
    - 29-Down, to Abe
 
    - Junior, maybe
 
    - Archie, to Meghan Markle
 
    - Certain heir
 
    - IV, to III, e.g.
 
    - Jacob, to Isaac
 
    - Will figure
 
    - Prince, but not a princess
 
    - Archie, to Prince Harry
 
    - III, to Jr., say
 
    - Father and Holy Ghost go-between
 
    - Jaden Smith, to Jada and Will
 
    - Ronan, to Mia Farrow
 
    - Dad bud, often
 
    - Richard chamberlain series:  "island ___"
 
    - End of many family business names
 
    - Potential beneficiary of nepotism
 
    - "Young man ..."
 
    - Certain youngster's nickname
 
    - Archie, to Meghan
 
    - Second part of the sign of the cross, symbolically
 
    - Singer Trinh Cong ___
 
    - Mars, to Jupiter
 
    - Possible nepotism beneficiary
 
    - Baby Archie, to Meghan Markle
 
    - Sir, to Beyonce and Jay-Z
 
    - Zeus, to Rhea
 
    - Common sitcom character
 
    - 43-Across, perhaps
 
    - Ganesha, to Parvati and Shiva
 
    - Boy in a family
 
    - Jr., to Sr., perhaps
 
    - ___ cubano (music genre)
 
    - Translation of "mwana"
 
    - Bart Simpson, to Homer
 
    - Jaden, to Will Smith
 
    - Richard Wright's "Native ___"
 
    - Daughter's sibling, perhaps
 
    - Sixth U.S. president vis-à-vis the second, e.g.
 
    - Heracles, to Zeus
 
    - Oceanus, to Gaia
 
    - Start of some sequel titles
 
    - Spanish for "are," or English for "hijo"
 
    - Relative in some business names
 
    - John David, to Denzel
 
    - John David, to Denzel Washington
 
    - #43, to #41
 
    - Bronny James, to LeBron James
 
    - Family member inaptly found in "ladies only"
 
    - Cronus, to Uranus
 
    - George or Louis, to William and Kate
 
    - ___-in-law
 
    - Zagreus, to Persephone, in "Hades"
 
    - Chaz, to Cher
 
    - Sir Carter, to Beyoncé
 
    - Luke, to Darth Vader
 
    - Chaz Bono, to Cher
 
    - "Favorite" or "prodigal" one
 
    - Family boy
 
    - Momma's boy
 
    - Patronizing term of address, perhaps
 
    - One might be a chip off the old block
 
    - The god Maui, to 'Akalana
 
    - Luke, to Anakin Skywalker
 
    - T'Challa, to Ramonda
 
    - II or III, perhaps
 
    - Kylo Ren, to Leia
 
    - Lenny Kravitz, to Roxie Roker
 
    - Bart, to Marge
 
    - Writer Joe Hill, to Stephen King
 
    - Pugsley, to Morticia
 
    - "Bye, ___": farewell from a buffalo's dad, in a classic joke
 
    - Author Joe Hill, vis-à-vis Stephen King
 
    - Telemachus, to Odysseus
 
    - BeBe, to Trudy, in "The Proud Family"
 
    - "Mushnik & ___" ("Little Shop of Horrors" song)
 
    - Bronny, to LeBron
 
    - O'Shea Jackson Jr., to Ice Cube
 
    - Kai, to Marlon Wayans
 
    - Eros, to Aphrodite
 
    - inFAMOUS: Second ___ (video game)
 
    - Not quite yet
 
    - The Second vis-à-vis the First, say
 
    - Homer Simpson, to Abe
 
    - Solomon, to King David
 
    - Word whose letters are aptly found from left to right in "scion"
 
    - Are, in Spanish
 
    - Jaden Smith, to Will Smith
 
    - "When you teach your ___, you teach your ___'s ___": the Talmud
 
    - One of 12 for Jacob
 
    - Peyton or Eli, to Archie