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Answer: ROANOKE
ROANOKE is a crossword puzzle answer that we have spotted 22 times.
Island where Virginia Dare was born
___ Colony (first English settlement in the New World)
___ Island, N.C.
Its nickname is "The Star City of the South"
Virginia city
With 38 Down, Blue Ridge Mountains city
First English colony in America
Island where the British first settled America
America's first English colony
Ill-fated colony
Lost Colony's island
Ill-fated Virginia colony
Virginia river
City in Virginia
Colony founded in the 1580s
City WSW of Richmond
The Star City of the South
Lost Colony island
Virginia city or river
Blue Ridge Mountains city
Virginia's so-called "Lost Colony"
Southwest Virginia city