Answer: QUE
QUE is a crossword puzzle answer that we have spotted 74 times.
    - "___ Sera, Sera"
 
    - "___ hora es?"
 
    - What's what in Spain
 
    - What, in Oaxaca
 
    - With 61-Down, start of a 1956 song title
 
    - "___ pasa?"
 
    - What's what in Mexico
 
    - Neighbor of N.Y.
 
    - "____ Sera, Sera"
 
    - Can. province
 
    - With 39-Across, a common greeting
 
    - N.Y. neighbor
 
    - Lab. neighbor
 
    - "___ sera, sera..."
 
    - Doris Day song title starter
 
    - Canadian prov.
 
    - What, to Juan
 
    - "Huh?" from Jose
 
    - Ont. adjoiner
 
    - Hernando's "Huh?"
 
    - Vt. neighbor
 
    - Neighbor of Ont.
 
    - Ont. neighbor
 
    - "¿___ pasa?"
 
    - Juan's "what"
 
    - Its flag has four fleurs-de-lis: Abbr.
 
    - "Eh?" in El Salvador
 
    - Home of the Nordiques: Abbr.
 
    - What's what, in the barrio
 
    - "¿___ tal?" ("¿Cómo estás?" alternative)
 
    - Prov. on James Bay
 
    - Canada's largest prov. in area
 
    - ''¿__ pasa?''
 
    - It's what's what in Mexico
 
    - "___ sera, sera ..."
 
    - 36-Across neighbor
 
    - Juan's "what?"
 
    - Montreals prov.
 
    - 'À___ pasa?'
 
    - '___ Sera Sera'
 
    - '___ Sera, Sera'
 
    - '___ pasa?'
 
    - José's "Huh?"
 
    - Doris Day's '___ Sera, Sera'
 
    - Juan's 'what'
 
    - Ont, neighbor
 
    - What, to Sergio
 
    - Neighbor of Vt.
 
    - It's north of Vt.
 
    - Prov. on the St. Lawrence
 
    - Where the Saguenay R. flows
 
    - What's what south of the border?
 
    - '¿___ pasa?'
 
    - Canadian prov. bordering Vt.
 
    - La Belle prov.
 
    - ' Sera, Sera'
 
    - That, in Paris
 
    - "___ linda!" ("How pretty!," in Spanish)
 
    - Spanish interrogative
 
    - Translation of "what"
 
    - Home of Montreal: Abbr.
 
    - Montreal's prov.
 
    - With 46 Down, Spanish "Sup?"
 
    - "What?," in Oaxaca
 
    - Spanish for "what"
 
    - Me. neighbor
 
    - "Por ___?"
 
    - "____ pasa?"
 
    - "___ onda?"
 
    - Spanish for what
 
    - What's what in Oaxaca
 
    - ___ pasa?
 
    - Letters at the end of a proof
 
    - "Huh?," in Honduras