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Answer: POISON
POISON is a crossword puzzle answer that we have spotted 37 times.
Corrupt
Pesticide
Kind of pen
Skull-and-crossbones stuff
Arrow application
It may feature Mr. Yuk on its label
Exterminator's option
Negative influence
Murder method in Christie's "A Pocket Full of Rye"
Something harmful
"Name yer ---"
Whodunit staple
Venom
Bane
Arsenic, for one
Whodunit item
Toxic substance
Toxic stuff
Contaminate
Hemlock, for one
Toxin
"Every Rose Has Its Thorn" monster-balladeers
Staple of Agatha Christie mysteries
What Mr. Yuk labels
Lethal substance
Cause of Romeo's death
It's toxic
Toxic thing
Malignant substance
Taint
Arsenic, e.g.
One of the nine weapons in 2008's expanded version of Clue
Downfall in many an Agatha Christie novel
"That girl is ___" (Bell Biv DeVoe lyric)
Bottle marked with a skull and crossbones
Substance symbolized by a skull and crossbones
Cause of death in some cozy mysteries