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Answer: PIUSI
PIUSI is a crossword puzzle answer that we have spotted 12 times.
First of 12 popes with a religious-sounding name
Canonized 2nd-century pope
Pope between Hyginus and Anicetus
Second-century pope
First of 12 popes
Ninth successor of St. Peter
Early pope
Sainted second-century pope
Sainted pope
First of twelve popes
2nd-cen. Pope
Pope of the mid-100s