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Answer: PIONEER
PIONEER is a crossword puzzle answer that we have spotted 26 times.
Avant-gardist
NASA program that explored the outer planets
Conestoga wagon passenger
Trailblazer
Panasonic rival
Go first
British Columbia mine
Davy Crockett, e.g.
Innovator
Pathfinder
Settler
___ 10 (first spacecraft to observe jupiter)
Daniel Boone, notably
Conestoga wagon traveler
Lead the way
First of a kind
Groundbreaker
Early resident
Boone or Crockett, notably
Explorer of new territory
Show the way
First in a field
Initiate
Trailblaze
Inaugurate
Lewis or Clark