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Answer: MIDEAST
MIDEAST is a crossword puzzle answer that we have spotted 14 times.
Perennial trouble spot
Palestine's locale
Region from Libya to Afghanistan
Frequent Security Council topic
Spot of conflict
Where 29 Down is
Biblical setting
Lebanon's locale
Home of many early civilizations
Arabian Peninsula locale
Israel's region
Hot spot, both literally and figuratively
Region of long-frustrated peace efforts
Region spanning three continents