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Answer: MADMAN
MADMAN is a crossword puzzle answer that we have spotted 15 times.
Bedlamite
Maniac
Nut
Lunatic
Loony
Many an old horror film scientist, e.g.
Asylum occupant
Wild and crazy guy
One ranting and raving
Kook
One granted asylum?
Wild and crazy guy?
Many an old-movie criminal mastermind
Gogol's Aksenty Poprishchin, per the title
Typical Spidey foe