Answer: ISAAC
ISAAC is a crossword puzzle answer that we have spotted 255 times.
    - Newton or Stern
 
    - Writer Asimov
 
    - Stern that works with a bow
 
    - Nearly sacrificed son
 
    - Soul singer Hayes
 
    - Violinist Stern
 
    - Composer Albéniz
 
    - Funk of Funk & Wagnalls
 
    - Father of biblical twins
 
    - Half-brother of Ishmael
 
    - Captain Hull, known as "Old Ironsides"
 
    - Capt. Hull who commanded Old Ironsides
 
    - Biblical patriarch
 
    - He was spared by divine intervention in Genesis
 
    - Stern with a bow
 
    - Father of famous twins
 
    - Hayes who sang "Never Can Say Goodbye"
 
    - Designer Mizrahi
 
    - Hayes who sang "Do Your Thing"
 
    - Stern or Hayes
 
    - Asimov or Stern
 
    - Stern with a violin
 
    - Father of well-known twins
 
    - Singer Hayes
 
    - Father of Esau
 
    - Esau's father
 
    - Author ___ Bashevis Singer
 
    - Publisher Funk of Funk and Wagnalls
 
    -     Stern who saved Carnegie Hall
 
    - 180-year-old in Genesis
 
    - 1960's-70's singer Hayes
 
    - ___ Pitman, who invented shorthand
 
    - Scientist __ Newton, who was supposedly inspired by a falling apple
 
    - Ishmael's half-brother
 
    - Caravaggio's "The Sacrifice of ___"
 
    - Sir ___ Newton
 
    - 10-Down's father
 
    - Biblical name meaning "laughter"
 
    - Asimov of sci-fi
 
    - Stern that bows
 
    - Singer of sewing machine fame
 
    - Prolific Asimov
 
    - Hall-of-Fame Nascar racer Bobby
 
    - Almost-sacrificed son in the Bible
 
    - Son of Sarah
 
    - Shorthand inventor Pitman
 
    - Newton with a law named after him
 
    - Sci-fi writer Asimov
 
    - Half brother of Midian, in the Bible
 
    - Stern, for one
 
    - Calculus inventor Newton
 
    - Asimov or Newton
 
    - Bartender on "The Love Boat"
 
    - "Shaft" composer Hayes
 
    - "I, Robot" author Asimov
 
    - Knighted Newton
 
    - "Don't Let Go" singer Hayes
 
    - Sci-fi author Asimov
 
    - Hayes who voices "Chef" on "South Park"
 
    - Author Asimov
 
    - With 33-Down, memorable violinist
 
    - Hayes of "South Park"
 
    - Abraham's son
 
    - Scientist Newton
 
    - Newton, Watts, or Hayes
 
    - Prolific writer Asimov
 
    - Newton with laws
 
    - Fashion-conscious Mizrahi
 
    - Asimov of science fiction
 
    - Father of Esau and Jacob
 
    - Writer ___ Bashevis Singer
 
    - Oldest brother in Hanson
 
    - Bartender on TV's Pacific Princess
 
    - Shorthand system inventor Pitman
 
    - Stern playing?
 
    - Jacob's father
 
    - Hayes who voices Chef on "South Park"
 
    - Rams wide receiver ___ Bruce
 
    - Fashion designer Mizrahi
 
    - "Foundation" author Asimov
 
    - "Gimpel the Fool" writer ___ Bashevis Singer
 
    - Pro Bowl wide receiver ___ Bruce
 
    - Big name in motion
 
    - Mathematician Newton
 
    - Abraham's near-sacrifice
 
    - Jacob's dad
 
    - Sir __ Newton
 
    - Newton's first name
 
    - Son of Abraham
 
    - Old Testament patriarch
 
    - "The Love Boat" character
 
    - ''Gimpel the Fool'' writer Singer
 
    - ''Shaft'' composer Hayes
 
    - Sarah's son
 
    - Mixologist on ''The Love Boat''
 
    - Child born to a 100-year-old father
 
    - ''Shaft'' singer Hayes
 
    - Newton of gravity fame
 
    - Newton knighted in 1705
 
    - Father of Jacob
 
    - ''Don't Let Go'' singer Hayes
 
    - Newton of apple legend
 
    - Soulful Hayes
 
    - Abraham's boy
 
    - Mixologist on "The Love Boat"
 
    - Bartender of TV
 
    - "Love Boat" drink mixer
 
    - Biblical father of twins
 
    - "The Love Boat" employee
 
    - Newton or Hayes
 
    - Big name in the study of gravity
 
    - "Shaft" singer Hayes
 
    - Stern violinist
 
    - Prophet of Islam
 
    - "The Love Boat" bartender
 
    - First name in sci-fi
 
    - "Theme from Shaft" writer Hayes
 
    - Stern with a bow?
 
    - Newton of physics
 
    - Stern with a Strad
 
    - "The Love Boat" barkeep
 
    - Newton with three laws of motion
 
    - Hayes or Newton
 
    - English theologian Watts
 
    - Deep-voiced Hayes
 
    - Abraham's almost-sacrificed son
 
    - "Gimpel the Fool" writer Singer
 
    - Sir Newton
 
    - Newton, for one
 
    - Physicist Newton
 
    - Pianist Albéniz
 
    - One spared in a sacrifice
 
    - "Shaft" theme writer Hayes
 
    - Abraham nearly sacrificed him
 
    - Mizrahi of "The Fashion Show"
 
    - Newton or Asimov
 
    - Gravity grasper Newton
 
    - Nearly sacrificed son of Abraham
 
    - Fashion designer Mizrahi
 
    - Stern with bows
 
    - Genius Newton
 
    - Stern or Singer
 
    - Violin virtuoso Stern
 
    - Stern or Newton
 
    - Jacob and Esau's dad
 
    - Violinist stern
 
    - Stern taking a bow (in two senses)
 
    - "Shaft" scorer Hayes
 
    - Stern with strings
 
    - Abraham's would-be sacrifice
 
    - R&B singer Hayes
 
    - "Love Boat" character
 
    - Newton who watched an apple fall from a tree
 
    - Son of Abraham and Sarah
 
    - Sir Newton, in situations of lower gravity
 
    - "Love Boat" bartender
 
    - Hayes or Asimov
 
    - Author ___ Asimov
 
    - Sci-fi's Asimov
 
    - Hull of the Constitution
 
    - Stern who bows
 
    - First name in calculus lore
 
    - British Columbia lake
 
    - With 16-Down, "Foundation" writer
 
    - Literature Nobelist ___ Bashevis Singer
 
    - Asimov who was extraordinarily prolifiC
 
    - Musician-actor Hayes
 
    - Singer-actor Hayes
 
    - Sci-fi-writer Asimov
 
    - Writer Babel
 
    - ___ Pitman, developer of shorthand
 
    - Newton who was knighted in 1705
 
    - Esau's dad
 
    - ___ Disraeli, author of "Curiosities of Literature"
 
    - Newton of science
 
    - ___ Watts, English hymnist who wrote "Joy to the World"
 
    - Genesis patriarch
 
    - He saw Esau
 
    - Singer ___ Hayes
 
    - Newton who formulated the law of universal gravitation
 
    - Singer of stories
 
    - Newton associated with apples, not figs
 
    - Thinker ___ Newton
 
    - Singer-songwriter Hayes
 
    - Name on the "Robot" series books
 
    - Oscar ___, star of "Inside Llewyn Davis"
 
    - Name on the cover of "I, Robot"
 
    - First name in gravity
 
    - "I, Robot" writer Asimov
 
    - Newton with a bump on the noggin
 
    - Science giant Newton
 
    - With 45-Across, "The Bicentennial Man" author
 
    - Father of Jacob and Esau
 
    - Mizrahi of fashion
 
    - Jacob's pop
 
    - Sir  Newton
 
    - Hayes of "Shaft" fame
 
    - With 12-Down, Carnegie Hall icon
 
    - Patriarch called a "Prophet" in the Koran
 
    - Hayes or Stern
 
    - Biblical forebear
 
    - Hayes who sang "Shaft"
 
    - Spanish composer Albeniz
 
    - Genesis father of twins
 
    - Hayes of music
 
    - Science fiction writer Asimov
 
    - Musical Hayes
 
    - A patriarch of the Israelites
 
    - Newton who was knighted
 
    - Actor Oscar ___ of "Star Wars: The Last Jedi"
 
    - Biblical son who was nearly sacrificed by his father
 
    - Biblical father of Jacob
 
    - Sir ____ Newton
 
    - Newton who lent his name to three laws of motion
 
    - Ancestor of Moses
 
    - Calculus pioneer Newton
 
    - Man's name that comes from the Hebrew for "laughter"
 
    - Hayes who scored "Shaft"
 
    - Joseph's grandfather
 
    - Newton with laws of motion
 
    - Physics pioneer Newton
 
    - Newton or Mizrahi
 
    - Israelite patriarch
 
    - Biblical figure with a tomb in the Cave of the Patriarchs
 
    - Biblical near-sacrifice
 
    - One spared by God in a Bible story
 
    - Singer/songwriter Hayes
 
    - Author Bashevis Singer
 
    - Oscar of "Inside Llewyn Davis"
 
    - Oscar with a Golden Globe
 
    - Hayes in the Rock and Roll Hall of Fame
 
    - Newton who studied gravity
 
    - Singer who founded a sewing company
 
    - Oscar of "The Last Jedi"
 
    - Hayes with three Grammys and an Oscar
 
    - Whom Sarah had in her early 90s
 
    - Name on the "Robot" sci-fi series
 
    - Oscar ___, player of Poe Dameron in "Star Wars" films
 
    - Poe Dameron actor Oscar
 
    - "Moon Knight" star Oscar ___
 
    - Oscar of 2021's "Dune"
 
    - Director Lee ___ Chung
 
    - Whom Abraham nearly sacrificed
 
    - Soul music legend Hayes
 
    - Yiddish singer?
 
    - Oscar ___, portrayer of Duke Atreides in "Dune"
 
    - Yiddish novelist ___ Bashevis Singer
 
    - Oscar of "Moon Knight"
 
    - "Foundation" series writer Asimov
 
    - Newton of apple fame
 
    - Literature Nobel laureate Bashevis Singer
 
    - Asimov who coined the term "robotics"
 
    - Oscar of "Dune"
 
    - Novelist Asimov
 
    - "Dune" star Oscar