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Answer: IRRITANT
IRRITANT is a crossword puzzle answer that we have spotted 12 times.
Poison ivy sap, e.g.
Cause of a rash
Dripping faucet, perhaps
Pain in the neck
Princess's pea, e.g.
Thorn in one's side
Pebble in one's shoe, e.g.
Smoke in one's eyes, say
Nuisance
Grain of sand, to a pearl oyster
Aggravation
Fly in the ointment