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Answer: IRK
IRK is a crossword puzzle answer that we have spotted 87 times.
Be a pain
Annoy
Provoke
Perturb
Ruffle
Bother
Tick off
Set off
Trouble
Peeve
Get one's goat
Tee off
Put out
Rankle
Get to
Rub the wrong way
Drive up the wall
Stick in one's craw
Grate on
Vex
Bug
Discommode
Nettle
Exasperate
Put in a pet
Get under the skin of
Get under one's skin
Get on the nerves of
Bug a bit
Miff
Aggravate
Chafe
Rile up
Be a thorn in the side of
Rile
Do some button-pushing, so to speak
Get on one's nerves
Ruffle the feathers of
Drive bananas
Make upset
Raise one's hackles
It may be in front of some
Gall
Irritate
Inflame
Drive to distraction
Make angry
Test the patience of
See 23-Across
Pester
Bug like a 24-Down
Rattle one's cage
Piss off
Needle
Make peeved
Anger
Really get to
Really ruffle
Make mad
Bug greatly
Drive up the wall, so to speak
Bother the heck out of
Trouble with vexations
Bug a lot
Bug or annoy
Really bug
Really pester
Bother a lot
Go against one's grain
Really annoy
Get disgruntled
Pique
Really bother
Run afoul of
Bug big-time
Try the patience of
Bug to distraction
Harass
Bedevil
Be a pest
Be wearisome to
Tickoff
Be a nuisance to
Bug to no end
Be a pain to
Cause to groan, maybe
Bug a great deal