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Answer: HYDRA
HYDRA is a crossword puzzle answer that we have spotted 42 times.
Victim of Hercules
Monster slain by Hercules
Nine-headed serpent of myth
Nine-headed serpent
Many-headed serpent
Monster in the second labor of Hercules
Victim of Hercules' second labor
Subject of a Herculean labor
Many-headed monster of myth
Monster with a head for multiplication and then some
Multiheaded serpent slain by Hercules
Many-headed monster
Sea Serpent constellation
Mythical serpent
Serpent with nine heads
Multiheaded beast slain by Hercules
Many-headed mythical monster
Beast that grew two heads every time it lost one
Many-headed challenge for Hercules
Longest constellation
Mythical multiheaded beast
Multiheaded monster
Resilient many-headed monster
Herculean opponent
Hercules' many-headed foe
Serpent slain by Hercules
See 21-Across
Freshwater polyp
Many-headed monster slain by Hercules
Creature Hercules fought
Monster raised by Hera
Beast battled by Hercules
Hercules slew it
Hercules' serpent adversary
S.H.I.E.L.D.'s enemy, in Marvel comics
One with many mouths to feed?
Southern constellation
Multiheaded monster of myth
Monster with many heads
Sea serpent in the night sky
Enemy organization in Marvel Comics
Multiheaded serpentine lake monster