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Answer: HOUSTON
HOUSTON is a crossword puzzle answer that we have spotted 22 times.
George Bush's home now
Two-time president of Texas
Astronauts' contact
Sam, who led the struggle to win control of Texas from Mexico
Texas president Sam
First word spoken to earth from the lunar surface
Rice University site
First Republic of Texas president
Largest city in Texas
Addressee of the 4/14/1970 message "we've had a problem"
Texas city
Brown's former partner
Home of the Rockets
"The Bayou City"
Home base for many a mission
Rice University home
Astros' home
Fourth-most populous U.S. city
Rice University city
Sam who won at the Battle of San Jacinto
Wealthy TV sleuth Matt
First word spoken on the moon, 1969