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Answer: HEADACHE
HEADACHE is a crossword puzzle answer that we have spotted 27 times.
Major annoyance
Problem
Annoying situation
Annoyance
Cephalalgia
Pain in the brain
Nuisance
Aspirin target
One reason for taking aspirin
Ibuprofen target
Major inconvenience
Big pain
Big bother
Migraine, for one
Vexatious problem
Bother
Migraine
Big problem
Vexing situation
Bothersome type
Worrying problem
Hangover symptom
Migraine, e.g.
Inconvenience
Pain in the butt, ironically
Source of worry
Something treated by Tylenol