Answer: ERIE
ERIE is a crossword puzzle answer that we have spotted 1000 times.
- Buffalo's lake
- Northwest Pennsylvania city
- Foe of the Iroquois
- Louis Jolliet discovery of 1669
- I-79 terminus
- Presque Isle locale
- View from Sandusky
- Welland Canal outlet
- Southernmost Great Lake
- Cleveland's lake
- I-79's northern terminus
- One of a watery quintet
- Native New Yorker
- Lackawanna's partner in railroading
- Canal with a "low bridge" ("ev'rybody down!")
- DeWitt Clinton's canal
- Canal with a mule named Sal
- Gannon University locale
- Iroquois enemy
- Lake near Jacobs Field
- Lake that feeds Niagara Falls
- Jolliet's 1669 discovery
- New York Indian
- Pelee Island's lake
- Toledo's lake
- New York's ___ Canal
- Cuyahoga's outlet
- New York and ___ Railroad, started in 1832
- A Great Lake
- Buffalo's county
- Where Oliver Hazard Perry prevailed
- Old railroad name
- Canal with a mule, in song
- New York canal
- Lake ___ College, in 16-Across
- Jay Gould railroad
- U.S. port, or its locale
- It's between Huron and Ontario
- Canal to the Hudson
- Pennsylvania city
- Superior's inferior
- An Iroquoian
- Where I-79 ends
- Lake near Niagara Falls
- Eastern Woodlands tribe
- Put-in-Bay's lake
- New York's most populous upstate county
- Iroquoian Indian
- Ashtabula's lake
- Pennsylvania port
- Gannon University city
- Sal's canal
- Part of the U.S./Canada border
- Classic railroad name
- Mercyhurst College site
- Niagara River source
- War of 1812 locale
- Old name in railroads
- The shallowest Great Lake
- Sandusky's county
- Strange-sounding city?
- Cleveland Indian
- War of 1812 port
- ___-Lackawanna Railroad
- Great Lakes Indian
- Keystone State port
- Canal of song
- ___ Railroad, founded 1832
- War of 1812 battle site
- Lake ___ Beach, N.Y.
- Oliver Hazard Perry victory site
- Lake along which I-90 runs
- Presque Isle lake
- Where Commodore Perry prevailed
- Enemies of the Iroquois
- Lake touching four states
- Tribe with palisaded villages
- Sandusky's lake
- Western New York county
- ___ Lackawanna Railroad
- City near Fort Presque Isle
- Penn State branch site
- Great Lakes port
- Fort ___, Ont.
- Iroquois foe
- View from the Rock & Roll Hall of Fame
- Lake tribe
- Great Lakes city
- Eastern tribe
- View from Toledo
- One of the HOMES five
- Port city or the lake it's on
- Behrend College locale
- Northwesternmost Pennsylvania county
- Railroad chartered in 1832
- Port on a lake of the same name
- Tribe defeated by the Iroquois
- Former lakeshore tribe
- Pennsylvania's northwesternmost county
- Niagara source
- New York county
- Lake on the U.S./Canada border
- ___ canal
- City on Presque Isle Bay
- With 34-Across, engineering feat completed in 1825
- Ohio/Ontario separator
- Lackawanna's lake
- Lake Indian
- Fort ___, captured by U.S. forces in 1814
- Lake named after an Indian tribe
- 1813 battle site
- Shallowest of the Great Lakes
- Canada's Battle of Fort ___, 1866
- Buffalo's body of water
- Iroquoian language
- Lake __, site of an 1813 U.S. naval victory
- Home of Gannon University
- New York tribe defeated by the Iroquois
- ___ Lackawanna (bygone railroad)
- Lake next to Avon Lake
- With 30-Down, locale of lots of locks
- City of 100,000+ or the lake it's on
- Lake ___, outlet of the Maumee River
- Pennsylvania's Flagship City
- Shallowest Great Lake
- Great Lake touching four states
- Canal near Rome
- Lake ___, south of London
- Lake ___, home of the Bass Islands
- War of 1812 siege site
- Upstate New York county
- County in New York, Ohio or Pennsylvania
- View from Buffalo
- Lake ___, discovery of Louis Jolliet
- Lake bordering four states
- Home of Presque Isle Downs racetrack
- See 5-Down
- Euclid's lake
- Toledo's waterfront
- Ontario neighbor
- Strange-sounding city
- Ontario's neighbor
- Part of HOMES
- Canal of Sal
- "that thing you do!" city
- HOMES body
- Early American
- De Witt Clinton's canal
- Southernmost of the Great Lakes
- Canal of Sal, in song
- Canal that opened in 1825
- Hudson River canal
- Toledo's water
- Quaker State city
- NW Pennsylvania port
- Sandusky Bay lake
- One of the Great Lakes
- Lake in four states and Canada
- Lake seen from the Rock and Roll Hall of Fame
- Part of H.O.M.E.S.
- Lake bordering Ontario
- Lake where Perry fought
- Buffalo's canal
- View from the Rock and Roll Hall of Fame
- The shallowest of HOMES
- Sal's canal, in song
- Middle Atlantic tribe
- City near Buffalo
- Canal backed by Clinton
- Niagara Falls feeder
- Keystone State city
- Empire State canal
- Canal opened in 1825
- Huron neighbor
- Pennsylvania port city
- Fourth of HOMES
- Lake of Commodore Perry's victory
- City on its own Great Lake
- Pennsylvania's fourth-largest city
- Buffalo is on its shore
- One of a wet quintet
- Only Pennsylvania county that borders New York and Ohio
- Lake or city
- Buffalo-to-Albany canal
- Lorain, Ohio's lake
- It's part of four states' borders
- Lake adjacent to the Rock and Roll Hall of Fame
- Presque Isle's lake
- Strange-sounding lake
- Ashtabula waterfront
- "We have met the enemy" there
- New York port
- Railroad launched in 1851
- Canal completed in 1825
- Great Lake
- Stop on Amtrak's Lake Shore Limited
- Canal that cost $7,143,789 to build
- Site of fighting in the War of 1812
- Lake that feeds the Niagara River
- Fourth largest of the Great Lakes
- First Great Lake, alphabetically
- Lake where Perry prevailed in 1813
- Where "We have met the enemy ..."
- Weird-sounding lake
- Pennsylvania lake port
- Northernmost Pennsylvania county
- Presque Isle Bay city
- Lake by the Jake
- Lake next to the Rock and Roll Hall of Fame
- Warmest of the Great Lakes
- Lake next to Cleveland
- Lake that touches New York and Ontario
- Lake on our northern border
- Body of water near Buffalo
- Port between Buffalo and Cleveland
- Pennsylvania's "Flagship City"
- Lake fed by the Sandusky River
- ___ Lackawanna
- New York's shortest-named county
- Tribe in the Great Lakes area
- Buffalo water hole
- See 68-Across
- Border lake
- Ohio county north of Huron
- Keystone State county
- Fourth-largest of the Great Lakes
- Penn State city
- Rival of Altoona in minor league baseball's Eastern League
- Port on its own lake
- Lake surrounding Canada's southernmost point
- Most of Ohio's northern boundary
- One of a noted quintet
- Lake-effect snow city
- Upstate New York's ___ Canal
- See 23-Across
- Pennsylvania county or its seat
- Niagara River's source
- Seat of Kansas's Neosho County
- New York county south of Niagara
- Home to Jerry Uht Park, where the SeaWolves play baseball
- Home port of the U.S. brig Niagara
- Buckeye State county
- Setting of "That Thing You Do!"
- Ohio's Lake ___ College
- Double A baseball team in the Eastern League's Southern Division
- Lake near London
- Birthplace of Billy Blanks
- Most populous county in upstate New York
- View from Canada's Point Pelee National Park
- Lake the Detroit River flows into
- Lake that Canada's Point Pelee National Park is on
- Lake on the border of four states
- Lake that the Huron River flows into
- City in the Quaker State
- Home of the Freeze indoor football team
- ___ Railroad Co. v. Tompkins (1938 Supreme Court decision)
- Northwesternmost county in Pennsylvania
- North American language
- Buffalo's lake and county
- "Mistake by the lake" lake
- City across the state from Philadelphia
- Pennsylvania county that borders New York and Ohio
- City in the minors' Eastern League
- With 36-Down, "Clinton's Ditch"
- Cat Nation tribe
- With 28-Down, New York waterway
- Lake that borders Ohio
- Lake surrounding Kelleys Island
- Ohio county
- Lake surrounding Pelee Island
- Lake that contains Canada's southernmost point
- Lake that Ohio's Lake County borders
- Ohio-Ontario separator
- Gannon University's home
- Railroad company known as "The scarlet woman of Wall Street"
- Niagara River feeder
- Northern terminus of I-79
- 1960 railroad merger company
- Part of a wet quintet
- Lake not far from Niagara Falls
- City known for lake-effect snow
- Mercyhurst College city
- Eastern city on I-90
- Presque Isle State Park's lake
- Home of the reconstructed USS Niagara
- Pennsylvania county, or its lake
- One of a notable quintet
- Detroit River outlet
- Weird-sounding lake?
- Cuyahoga River outlet
- Pennsylvania port or its lake
- Water by Buffalo
- Lake bordering Ohio
- Old Ohio/New York tribe
- Pennsylvania's fourth largest city
- Lake that's the outlet for the Detroit River
- Lake seen from Monroe, Michigan
- Site of a significant War of 1812 victory
- View from Sandusky, Ohio
- New York canal opened in 1825
- __ Lackawanna Railroad
- The "E" in HOMES
- Canal to the Hudson River
- Lake from which the Niagara River flows
- War of 1812 battle locale
- Lake north of Cleveland
- Onetime New York Indian
- Lake bordering New York
- Only four-letter Great Lake
- Great Lake bordering Pennsylvania
- Where the Detroit River ends
- Historic canal
- Lake near Cleveland
- Part of Ohio's border
- Sight from Sandusky
- HOMES part
- Pennsylvania neighbor
- Joliet discovery of 1669
- Perry victory site
- Huron's neighbor
- Eastern port
- Source of the Niagara River
- Lake fed by the Cuyahoga River
- ''Lake effect snow'' city
- Lake north of Ohio
- Put-in-Bay's locale
- County east of Ashtabula
- Small Great Lake
- Port of Pennsylvania
- Cleveland's water
- One of a lake quintet
- Detroit River destination
- Pennsylvania's lake port
- City southwest of Buffalo
- Lake fed by the Detroit River
- Canal of renown
- One of five Great ones
- Albany-to-Buffalo canal
- Welland Canal terminus
- Buffalo shore
- Barge canal of song
- Sal the mule's canal
- Quaker State port
- Clinton's Ditch (canal)
- "... 15 miles on the ___ Canal"
- "... fifteen miles on the ___ Canal"
- Strange-sounding canal?
- Clinton's waterway
- It's inferior to Superior
- Spooky-sounding lake
- Seneca foe
- Clinton's Big Ditch
- Albany canal
- Great Lakes name
- ___ Lackawanna Railway
- Discovery some attribute to Jolliet
- U.S.-Canada border lake
- Albany's canal
- Canal connecting the Great Lakes to the Atlantic
- Pennsylvania harbor city
- Big lake
- Detroit River's destination
- Lake, city or canal
- Lake feeding the Niagara River
- Port in Pennsylvania
- One of five great waterways
- Buffalo's waterfront
- One of the Great ones
- Northeastern U.S. canal
- Pennsylvania's Great Lakes port
- Lorain's lake
- Superior relative?
- One of the Niagara River's sources
- One of a noted geographical quintet
- ". . . fifteen miles on the ___ Canal"
- Fourth-largest Great Lake
- War of 1812 lake
- 15 miles of it are mentioned in a song
- Commodore Perry's victory site
- "Low bridge, everyone down!" canal
- Tribe once found around Buffalo
- Lake in view from Cleveland
- It washes 50-Down
- Iroquois enemies
- Fabled canal
- One of Jay Gould's railroads
- Large lake named after a tribe
- Canal of Rome
- HOMES member
- Lake in four states
- Superior neighbor
- Cleveland's body of water
- Large freshwater lake
- Canal to Buffalo
- Lake named for an Indian tribe
- City north of Pittsburgh
- Canal or lake
- Ohio-Ontario divider
- Port city of Pennsylvania
- Sight from the Rock and Roll Hall of Fame
- Canadian border lake
- First American canal
- Eleventh largest lake in the world
- Buffalo water
- Clinton's canal
- Ashtabula's water
- Sal the mule's domain
- Ontario-Huron link
- Niagara's source
- Jolliet discovery
- B&O rival
- 15 miles of song
- Smallest Great Lake, in volume
- Famous canal
- American canal
- Part of Pennsylvania's border
- Southernmost of a wet quintet
- City near Presque Isle
- Smallest Great Lake in volume
- Big name in railroads
- Ohio tribe
- Lake that sounds spooky
- Canal depicted on New York's state quarter
- Pennsylvania's only Great Lakes port
- Great Lake port
- County west of Wyoming
- Lake on four states and a province
- It feeds Niagara Falls
- New York state canal
- "Fifteen Miles on the ___ Canal"
- One of the HOMES lakes
- Name of a lake or canal
- One of a "Great" quintet
- Canal that Sal worked on, in song
- ___ Canal, waterway through Schenectady
- City or lake
- Losing tribe in the Beaver Wars
- Great Lake bordering New York
- City on a same-named lake
- Lake near the Rock and Roll Hall of Fame
- Part of Ontario's southern border
- Lake adjoining Ontario
- Admiral Perry victory site
- Source of the Niagara
- Detroit River's terminus
- Buffalo's county or lake
- Canal by Buffalo
- City not far from Buffalo
- "that thing you do!" setting
- War of 1812 shipbuilding port
- County in New York, Ohio, and Pennsylvania
- View from Presque Isle
- Pennsylvania county
- Crossword constructor's favorite canal
- Jay Gould's railroad
- Shallowest of the Great ones
- Lake of the Bass Islands
- "Lake effect snow" city
- Canal that parallels much of the Mohawk River
- View from Cleveland
- Home of Oliver Hazard Perry's flagship Niagara
- Lake southwest of Lake Ontario
- Great Lakes tribe
- U.S. Brig Niagara's port
- Neighbour of Huron
- Ontario neighbour
- Soft cheese
- Lake above Ontario
- One of the Greats?
- Ontario's Fort ______
- Great one?
- One of the five
- Neighbour of Ontario
- Lake near Buffalo
- Canal that parallels much of the Mohawk River
- City that's home to the U.S. Brig Niagara
- City north of Pittsburg
- City near Presque Isle State Park
- One of the Greats
- "15 miles on the ___ Canal"
- Canal from Albany
- Ontario's Fort ___
- Smallest Great Lake, by volume
- Canal for Sal, in a song
- 14-Across's Great Lake
- Buffalo's country
- Lake into which Ohio's Cuyahoga River empties
- Part of the HOMES mnemonic
- Canal for Sal
- Tribe native to Ohio
- Canal zone?
- View from Huron, Ohio
- Home of the Detroit Tigers' minor-league affiliate SeaWolves
- Rust Belt port
- One of the Lower Lakes
- See 11 Down
- Clinton's "Big Ditch"
- Pennsylvania city, or its lake
- Tribe that lent its name to a canal
- Waterford locale
- Northwestern Pennsylvania city
- Iroquoian language
- Lake where Perry achieved an 1813 victory
- Name of counties in three states, all crossed by I-90
- Pennsylvania or New York county
- City with a Penn State campus
- Part of the mnemonic HOMES
- One of HOMES
- Canal city
- Canal zone
- American lake
- Sight from Buffalo
- Pennsyl-vania port
- Buffalo borderer
- Cincinnati sight
- Neighbor of Huron
- One of a Great quintet
- See 39-Down
- Where 'We have met the enemy ...'
- Great quintet member
- Buffalo's water
- Pennsylvania port
- Pennsylvania city
- Cedar Point's lake
- U.S. border lake
- With 66-Across, Albany-to-Buffalo waterway
- Lake ___
- See 45-Down
- Lake between Huron and Ontario
- Cleveland's waterfront
- Creepy lake?
- Lake depicted on Michigan's state quarter
- A great lake for sailing?
- Lake near Lake Ontario
- 19th century canal name
- Creepy-sounding lake name?
- Great Lake with walleye
- Neighbor of Ontario and Huron
- View from Presque Isle State Park
- Tribe for which a canal was named
- Lake south of Niagara Falls
- Great Lake between Huron and Ontario
- County in Pennsylvania or New York
- Pennsylvania city or county
- See 29-Across
- The Maumee flows northeast to this lake
- Lake visible from the Rock and Roll Hall of Fame
- County east of Sandusky
- Source of lake effect snow in Cleveland
- Waters by Buffalo
- Lake between Ohio and Ontario
- Pennsylvania city on a same-named lake
- Battle site of 1813
- New York State's ___ Canal
- Northwestern Pennsylvania county
- Fort ___, Ontario
- County in both Pennsylvania and New York
- Oliver Perry victory site
- With 72-Across, waterway that opened in 1825
- Lake on the Pennsylvania coast
- Clinton's Folly canal
- Pennsylvania city of about 100,000
- Water east of Toledo
- Lake connected to Sandusky Bay
- Lake near Chautauqua
- Notable canal
- ___ Railroad, 1832-1960
- Certain Iroquoian
- Mercy Hurst College site
- HOMES component
- Stop on the Lake Shore Limited
- City SW of Buffalo
- Iroquois tribe member
- Perry battle site
- Lake ___, 1813 battle site
- Pennsylvania's northernmost county
- Homonym of 54 Down
- Buffalo's waters
- Railroad directed by Jay Gould
- Language related to Wyandot
- Lake separated from Lake Ontario by the Niagara River
- Eastern tribe overcome by the Iroquois
- 1813's Battle of Lake ___
- "Walleye Capital of the World"
- Lake next to Cedar Point amusement park
- Scary-sounding lake
- Smallest of five Greats
- Presque Isle Bay port
- "Low bridge! Everybody down!" canal
- Pennsylvania lake
- Iroquoian people
- Canal from the Great Lakes
- Lakeside Pennsylvania city
- It's fed by the Cuyahoga
- Lake ___, source of the Niagara River
- Canal for 43-Down
- Port 'twixt Buffalo and Cleveland
- Creepy-sounding lake
- Perry Square locale
- High-snowfall Eastern city
- Lake between Ontario and Huron
- Lake ___ College, near Cleveland
- Source of lake-effect snow in Cleveland
- City between Cleveland and Buffalo
- Port that's on its own lake
- Weird sounding canal?
- Smallest Great Lake by volume
- City on its own lake
- Great Lake name
- Major U.S. lake
- Canal that originally had 83 locks
- Canal with 36 locks
- It's at one end of I-79
- Lake site of a War of 1812 battle
- Noted canal
- Rock and Roll Hall of Fame's lake
- Lackawanna partner
- Iroquois foe in the Beaver Wars
- Lake in an old railroad name
- Lake at southernmost point of Canada
- Lake or canal
- Iroquois tribe
- Huron's neighbour
- Home of the Double-A SeaWolves
- US border lake
- Snowbelt city
- County name in three states
- Buffalo waters
- County south of Niagara
- Buffalo body
- Lake bordering Buffalo
- Home port of the brigantine "Niagara"
- New York county whose seat is Buffalo
- Spooky waterway?
- Lake at one end of the Niagara River
- Water due south of London
- Shipwreck divers' mecca
- Rust Belt city
- Eponymous Indian tribe
- They warred with the Iroquois
- Lakeside tribe
- Stop on Amtrak's Lake Shore Limited route
- U.S. city that's an anagram of 22-Across
- Great Lakes lake
- Lake below Huron
- Fifth largest Canadian lake
- City seen from Presque Isle State Park
- Famed canal
- Spooky-sounding Pennsylvania city
- "Great lake" for sailing
- New York county on the Canadian border
- Member of a noted quintet
- Buffalo county
- City of NW Pennsylvania
- City in NW Pennsylvania
- Lake of an 1813 battle
- Home port for the USS Niagara
- Erstwhile Iroquoian language
- Lake north of Sandusky
- Insurance company based in Pennsylvania
- Lake on New York's western border
- City facing Presque Isle Bay
- Water that sounds weird
- The "E" of the old NY&E Rail Road
- Waterway by Buffalo
- Ontario border lake
- A U.S. lake or canal
- Lake adjoining Cleveland
- Lake adjoining Toledo
- It's great for boating?
- Wyandot's cousin
- The 'E' of HOMES
- Lake west of Ontario
- Water beside Buffalo
- Pennsylvania snowbelt city
- The Gem City, so-called because of its sparkling lake
- City where Perry's flagship Niagara is exhibited
- Lake on Ohio's northern border
- City on a lake of the same name
- Source of Niagara Falls
- HOMES element
- Commodore Perry victory site
- "HOMES" part
- A Penn State campus site
- Lake that sounds strange
- Another HOMES part
- Ohio lake
- Neighbor of 12-Down
- Commodore Perry's lake
- Buffalo's county and lake
- Mercyhurst University city
- "Great" lake for sailing
- Lake view from Toledo
- Shortest Great Lake name
- Lake that stretches from Toledo to Buffalo
- American tribe
- Lake ___, home of Presque Isle
- Cleveland's Great Lake
- The "E" of HOMES
- Lake that's great
- Shallowest HOMES member
- Name of a noted canal or lake
- Lake that anagrams 43-Down
- Lake seen from Toledo
- Maumee Bay's lake
- Ohio border lake
- Great Lake bordering four states
- Lakeside Ohio county
- City or lake near Buffalo
- Canal past Rochester
- Lake linked to the Hudson River
- Buffalo's great lake
- Pennsylvania city or the lake it's on
- City, canal and lake
- Border lake or canal
- Cuyahoga River's destination
- What surrounds Canada's southernmost land
- Eastern native
- No Clue
- Port with lots of lake-effect snow
- A Penn State campus city
- Jolliet's lake
- Canal through Oneida Lake
- Port in the Keystone State
- Former tribe in western New York
- It's down the lake from Buffalo
- City on Amtrak's Boston-to-Chicago line
- Lake connected with lake-effect snow
- Point Pelee's lake
- Pennsylvania's "Gem City"
- It's southeast of London
- Great Lake or canal
- Canal serving Rochester
- Railroad name starting in 1832
- Lake bordering four states and a province
- Canal with 35 locks
- Border lake or canal
- Canal or Great Lake
- Home to Double-A baseball's SeaWolves
- Canal of New York
- Lake beside Buffalo
- Big name in canals
- Shallowest of the HOMES quintet
- Euclid, Ohio's lake
- "Lake-effect snow" lake
- Pennsylvania port, or its waters
- Canal called "Clinton's Ditch"
- Pennsylvania city subject to lake-effect snow
- It's southwest of Buffalo
- Lake source of the Niagara River
- Storied canal
- Railroad or lake
- With 33 Across, 1820s engineering marvel
- A U.S. canal
- Niagara Falls source
- The "E" in the HOMES mnemonic
- Water beside Toledo
- Ohio or New York county
- Source for Niagara Falls
- Pa. port
- Lake named for a tribe
- Lake beside Cleveland
- Lake Huron's neighbor
- Coloratura mills
- Three-voweled lake
- Canal called "Clinton's folly"
- Lake to the Hudson
- Of the Great Lakes, only Ontario is smaller than it
- It borders Toledo
- Lake, canal or city
- HOMES fourth
- Huron and Ontario connector
- Smallest of the Great Lakes
- Pennsylvania
- City on a namesake lake
- A 64-Across border lake
- One-consonant lake
- See 61 Down
- Large northern lake
- Water bordering four states
- Fourth in a moist mnemonic
- Detroit River's outlet
- Lake near Progressive Field
- Eastern city whose name sounds weird?
- Canal near Canada
- Lake crossed traveling from Ohio to Ontario
- Sandusky River's lake
- Cleveland's waters
- Home to Bessie, a lake monster in American folklore
- Lake near a falls
- Lake that's a homophone of 59-Across
- Lake named for a Pennsylvania people
- Its main inlet is the Detroit River
- Buffalo lake
- Sal's canal of song
- Expanse north of Akron
- It's a two-hour drive north of Pittsburgh
- Port north of Pittsburgh
- Ohio's Great Lake
- Water near Niagara Falls
- Only Great Lake that borders Pennsylvania
- Pennsylvania lake city
- Welland Canal lake
- Detroit River's lake
- Great Lake named for a tribe
- 60-Across-sounding lake
- Haunted-sounding lake
- Canal about which the 1905 song "Low Bridge, Everybody Down" was written
- ___ Railroad Co. v. Tompkins (landmark 1938 Supreme Court case)
- One of five Greats
- West end of the Saint Lawrence Seaway
- Lake north of Akron
- City that sounds spooky
- Canal across New York
- Canal, lake and city name
- Rochester's canal
- Vowel-rich lake
- Lake ___ (what separates Ohio and Ontario)
- Where I-90 and I-79 meet
- Lake-effect snow lake
- Lake ultimately fed by 15-Across
- Lake bordered by four states and a province
- Lake named by an Iroquoian tribe
- 1813 battle site in the War of 1812
- Pennsylvania city known for lake-effect snow
- City by Lake Erie's south shore
- Canal that helps connect the Great Lakes to the Atlantic
- What the "E" stands for in HOMES
- Great Lake city
- Great Lake bordered by Ohio
- Part of Ontario's border
- New York county by a Great Lake
- Lake that drains via the Niagara River
- Fourth-largest city in Pennsylvania
- Shortest-named Great Lake
- Part of the mnemonic device HOMES
- A Great 53 Across
- Fort ___ (town on the Niagara)
- New York native
- Hudson-to-Niagara River canal
- Only Great Lake bordering Pennsylvania
- Shallowest of five
- Canal to the Great Lakes
- Lake south of London
- Native American tribe with a namesake lake
- Lake with a namesake canal
- Lake beside Huron, Ohio (really!)
- Water bordering Ohio
- Great Lake near Niagara Falls
- Lake west of Buffalo
- Pennsylvania's Great Lake
- Ashtabula's Great Lake
- Great Lake with the shortest name
- Toronto-to-Columbus midpoint
- Tribe that lived by a Great Lake
- Lake with an unsettling-sounding name
- Native people after whom a Great Lake is named
- Pennsylvania city on a Great Lake
- Canal through Lockport, New York
- Lake, canal, city, county or tribe
- Lake that feeds into Lake Ontario
- Lake by the Ontario Peninsula
- Great Lake named for an Iroquoian people
- Lake by Buffalo
- Pennsylvania city by a lake
- Lakeside city northeast of Cleveland
- Lake with Canada's southernmost point
- A Michigan water border
- Lake near Detroit
- Northwest county of Pennsylvania
- Tribe that fought the Iroquois
- Lake largely fed by the Detroit River
- Lake south of Huron
- City in northwestern Pennsylvania
- Lake that's the "E" in HOMES
- The "E" in the mnemonic HOMES
- Lake bordering Cleveland
- Great Lake with the smallest volume
- County name in New York, Ohio and Pennsylvania
- The lake in "lake effect" snow
- Lake on the U.S.-Canada border
- ___ Canal, New York
- Lake with a spooky-sounding name
- People with a namesake Great Lake
- City roughly halfway between Cleveland and Buffalo
- Frightening-sounding Great Lake
- Canal that roughly parallels I-90 in New York
- Great Lake that stretches from New York to Michigan
- Alphabetically, the first of the Great Lakes
- Great Lake that borders Cleveland
- Historic enemy of the Iroquois
- Buffalo backdrop
- Lake with an Ontario shore
- ___ Canal, connector of the Hudson River to the Great Lakes
- One of a "Great" five
- Most common lake in crosswords
- Spooky-sounding lake?
- Great Lake whose main outlet is the Niagara River
- Native people for whom a Great Lake is named
- Great Lake that borders Ohio
- Great Lake with 871 miles of shoreline
- People who lived in present-day Ohio, New York and Pennsylvania
- Alphabetically first Great Lake
- Lake south of London, Ontario
- City at the intersection of I-90 and I-79
- Lakeside city that's at one end of I-79
- Pennsylvania city home to Waldameer & Water World
- People also known as the Cat Nation
- Lake with the same first and last letter
- Cleveland is on its shore
- People for whom a Great Lake is named
- Lake hidden backward in "heiress"
- Historic trade ally of the Monacan people
- Ohio's lake
- Great Lake near Detroit
- Superior cousin?
- One in a wet quintet
- Great Lake near the 216
- Fort ___ (Peace Bridge terminus)
- Fourth letter in a famous mnemonic
- Northernmost county of Pennsylvania
- Pennsylvania city on I-90
- Great Lake named for a Native people
- Where Oliver Hazard Perry said "We have met the enemy, and they are ours"
- Empire State county
- Great Lake home to Pelee Island
- Lake spelled by removing one letter from "eerie"
- Great Lake near the Pro Football Hall of Fame
- City halfway between Buffalo and Cleveland
- Second-smallest Great Lake by area
- Pennsylvania city home to Presque Isle State Park
- Lake whose name comes from Iroquoian for "long tail"
- Great Lake whose average depth is 62 feet
- ___ Canalway Trail: 365-mile stretch in New York
- Great Lake with a namesake city in Pennsylvania
- Lake into which the Cuyahoga empties
- Great Lake with a lot of walleye
- Great Lake near Cleveland
- Lake south of Ontario
- Great Lake near Buffalo
- City in Pennsylvania
- Water buffalo
- See 67-Across
- Lake near Buffalo, New York
- Pelee Island's Great Lake
- Great Lake that sounds like a synonym for "spooky"
- Warmest Great Lake
- Lake that's home to South Bass Island
- Lake that drains into the Niagara
- Maumee River endpoint
- ___ Canalway Trail (360-mile bike path)
- Great Lake that touches four states
- Great Lake bordering Ohio
- Lakefront city between Cleveland and Buffalo
- Great Lake with the most abundant fish population
- Canal with a museum in Syracuse
- Historical allies of the Huron
- Great Lake with the shortest average water residence time
- Canal written about by Twain and Melville
- Cleveland abuts it
- Lake home to the cryptid "Bessie"
- Lake by Cleveland
- Lake bordering Ohio and New York
- Lake containing Rattlesnake Island
- Member of a wet quintet
- Great Lake by Cleveland
- Pennsylvania city across from Presque Isle State Park
- Indigenous people of northern Ohio
- Put in ebay's great lake
- Pennsylvania's Gem City
- Lake near the Rock & Roll Hall of Fame
- Toledo's Great Lake
- Pennsylvania city bordering a Great Lake
- Great Lake with a vowel-heavy name
- Smallest Great Lake
- Pennsylvania city that's home to Gannon University
- Locale for a noted canal
- Great Lake popular with divers
- Member of a "Great" quintet
- Pennsylvania home of minor-league baseball's SeaWolves
- Scary-sounding Great Lake
- Indigenous people of western New York
- Coastal Pennsylvania town
- Lake that surrounds Kelleys Island
- Lake that's largely fed by the Detroit River
- Great Lake that drains into the Niagara River
- Cedar Point's county and lake
- Great Lake that flows into Niagara Falls
- Great Lake with frequent storms
- Lake ___, body of water about 120 miles south of London
- Western Pennsylvania city
- Creepy-sounding Great Lake
- Canal with a "low bridge" ("Everybody down!")
- Great Lake prone to algae
- Rock & Roll Hall of Fame's lake
- Great Lake with the most consumable 26-Down
- Spooky-sounding Great Lake
- Lake that's home to Kelleys Island
- Sandusky's Great Lake
- Member of a watery quintet