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Answer: EPIDEMIC
EPIDEMIC is a crossword puzzle answer that we have spotted 15 times.
Rampant
Not localized
Great Plague, e.g.
Widespread outbreak
Uncontrolled outbreak
Flu outbreak, e.g.
Black Death of 14th century Europe, for one
Widespread
Widespread illness
Prevalent and rapidly spreading
Serious flu outbreak, e.g.
Rapid spread of a disease
Ebola outbreak of 2014, e.g.
Marked by widespread growth
Happening all over