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Answer: DESPAIR
DESPAIR is a crossword puzzle answer that we have spotted 22 times.
Give up
Film noir feature
Hopelessness
Bad thing to sink into
Give up all hope
Loss of hope
Down state
Abandon hope
Hopeless feeling
Lose hope
Heartache
Lose heart
Very blue state
Woe
Utter hopelessness
Hopeless
Low state
Give up hope
"The shadow of a starless night," per Percy Bysshe Shelley
"...there is nothing better for me than that i should speedily escape into the land of the philistines; and saul shall ___ of me..." (1 sam. 27:1)
Feeling of hopelessness
Lose all hope