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Answer: COCAINE
COCAINE is a crossword puzzle answer that we have spotted 16 times.
Anesthetic, once
Some contraband
Ingredient of a speedball
Holmes's vice
Old anesthetic
Drug from Colombia
Illicit drug
Addictive narcotic
Euphoric drug
Illegal psychostimulant
"snow" to a drug dealer
Ingredient in a Brompton cocktail
Powerful drug
Drug once used in anesthesia
Illegal import from Colombia
Subject of 2001's "Blow"