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Answer: CAFFEINE
CAFFEINE is a crossword puzzle answer that we have spotted 13 times.
It can keep you up
Red Bull ingredient
Substance in 95 Across
Cola ingredient
Joe's stimulant
Upper that's legal to down
Stimulant in 36-Down
Tea stimulant
Mild stimulant
Stimulant in coffee
The jolt in joe?
It provides the kick in coffee
Coffee's 'kick'