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Answer: ALCOHOL
ALCOHOL is a crossword puzzle answer that we have spotted 28 times.
Prohibitionists would like to prohibit it
Driving hazard
Spirits
Matter of proof?
See 71-Across
Second part
Still stuff
What virgin drinks lack
It separates wine from Welch's
Cider "hardener"
Still spirits
Fifth element?
It comes in fifths
Scourge of prohibition
See 40-Across
Prohibition's prohibition
Dipsomaniac's bane
Booze
Hooch
Rubdown bracer
Proof measures it
See 39 Across
Speakeasy attraction
Germ killer
"The anesthesia by which we endure the operation of life": Shaw
Virgin drink's lack
Purchase of proof?
"The cause of, and solution to, all of life's problems," per Homer Simpson